CAR-T cell therapy
Cell therapy, immune engineering, toxicity, relapse, manufacturing, and translational oncology papers.
Research topics
Focused entry points into the research feed
These pages highlight active research areas and open directly into PaprFeed searches across PubMed, arXiv, bioRxiv, and medRxiv.
BCMA CAR-T
BCMA-targeted cellular therapy for multiple myeloma and plasma-cell disorders.
CD19 CAR-T
CD19-directed CAR-T research in lymphoma, leukemia, autoimmune disease, and B-cell depletion.
Antibody drug conjugates
ADC targets, payloads, linkers, resistance, safety, and clinical development.
Flow cytometry
Cell phenotyping, immune profiling, sorting, panels, and cytometry analysis methods.
Single-cell RNA sequencing
Single-cell transcriptomics, atlases, immune profiling, and computational workflows.
Spatial transcriptomics
Tissue maps, spatial omics platforms, tumor microenvironment studies, and analysis methods.
CRISPR gene editing
Genome editing, delivery, off-target analysis, screening, and therapeutic applications.
Cancer immunotherapy
Checkpoint blockade, cell therapy, vaccines, biomarkers, and immune-oncology mechanisms.
AI in medicine
Clinical AI, medical imaging, prediction models, evaluation, and implementation research.
LLMs in medicine
Large language models for clinical support, biomedical writing, safety, and evaluation.
Neuroscience
Neural circuits, cognition, neurodegeneration, neuroimaging, and computational neuroscience.
Microbiome
Gut microbiota, host-microbe interactions, metagenomics, and microbiome therapeutics.
Vaccine research
Vaccine platforms, immune responses, adjuvants, effectiveness, and clinical evaluation.
Alzheimer's disease
Neurodegeneration, biomarkers, amyloid, tau, imaging, genetics, and therapeutic studies.
Parkinson's disease
Movement disorders, alpha-synuclein, neuroprotection, genetics, and clinical research.
Diabetes
Type 1 and type 2 diabetes, metabolism, insulin biology, complications, and therapy.
Obesity
Metabolic disease, appetite biology, incretin therapies, inflammation, and public health.
Cardiovascular disease
Heart disease, atherosclerosis, heart failure, risk prediction, and cardiovascular trials.
Infectious diseases
Pathogens, host response, diagnostics, antimicrobial resistance, outbreaks, and vaccines.
mRNA vaccines
mRNA platforms, lipid nanoparticles, immunogenicity, safety, and next-generation vaccines.
Immunology
Innate and adaptive immunity, inflammation, immune regulation, and translational immunology.
Tumor microenvironment
Immune cells, stroma, spatial biology, myeloid suppression, and therapy resistance.
Proteomics
Mass spectrometry, protein expression, biomarkers, single-cell proteomics, and methods.
Metabolomics
Metabolic profiling, biomarkers, pathway analysis, disease metabolism, and analytical methods.
Cell therapy
Engineered cells, immune-cell therapies, stem cells, manufacturing, and clinical translation.
Gene therapy
Viral vectors, nonviral delivery, genetic disease, safety, editing, and clinical studies.
Organoids
Stem-cell models, disease modeling, drug testing, cancer organoids, and tissue development.
Drug discovery
Targets, screening, medicinal chemistry, AI design, biomarkers, and translational development.
Clinical trials
Trial design, endpoints, biomarkers, safety, real-world evidence, and clinical outcomes.
Public health
Population health, prevention, health policy, screening, equity, and global health studies.
Epidemiology
Disease patterns, cohort studies, risk factors, surveillance, causal inference, and outbreaks.
Multiple myeloma
Plasma-cell malignancy research, immunotherapy, BCMA targeting, relapse biology, and treatment outcomes.
Lymphoma
Lymphoma research across immunotherapy, targeted therapy, biomarkers, pathology, and clinical outcomes.
Leukemia
Acute and chronic leukemia research, genetics, immune therapy, minimal residual disease, and trials.
Solid tumor CAR-T
CAR-T research for solid tumors, trafficking, antigen selection, tumor microenvironment, and resistance.
Allogeneic CAR-T
Off-the-shelf CAR-T research covering gene editing, rejection, persistence, safety, and manufacturing.
CAR-T toxicity
Cytokine release syndrome, ICANS, inflammation, risk prediction, management, and long-term safety.
Cytokine release syndrome
Inflammatory toxicity research in cellular therapy, immunology, biomarkers, and clinical management.
Immune checkpoint inhibitors
Checkpoint blockade research, response biomarkers, resistance, toxicity, and combination immunotherapy.
PD-1 blockade
PD-1 and PD-L1 inhibitor research in oncology, biomarkers, resistance, and immune-related toxicity.
Neoantigen vaccines
Personalized cancer vaccine research, antigen prediction, T cell responses, and clinical translation.
T cell exhaustion
T cell dysfunction, chronic antigen exposure, checkpoint biology, epigenetics, and immunotherapy response.
Regulatory T cells
Treg biology, immune tolerance, autoimmunity, cancer immunology, and therapeutic targeting.
NK cell therapy
Natural killer cell engineering, innate immunotherapy, persistence, targets, and clinical studies.
Macrophage biology
Macrophage polarization, inflammation, tissue repair, tumor-associated macrophages, and immunometabolism.
Dendritic cells
Antigen presentation, immune priming, vaccines, tolerance, and dendritic-cell immunotherapy.
Autoimmune disease
Immune dysregulation, autoantibodies, cell therapy, biologics, biomarkers, and clinical outcomes.
Lupus
Systemic lupus erythematosus research, autoantibodies, immune cells, nephritis, therapy, and outcomes.
Rheumatoid arthritis
Inflammatory arthritis research, biologics, biomarkers, synovium, remission, and clinical trials.
Inflammatory bowel disease
Crohn disease and ulcerative colitis research, microbiome, inflammation, biologics, and outcomes.
Multiple sclerosis
Neuroimmunology, demyelination, biomarkers, imaging, disease-modifying therapy, and progression.
Rare diseases
Rare disease genetics, diagnosis, natural history, gene therapy, registries, and clinical development.
Precision oncology
Molecular profiling, biomarkers, targeted therapy, resistance, basket trials, and treatment matching.
Liquid biopsy
Blood-based cancer diagnostics, ctDNA, minimal residual disease, monitoring, and early detection.
ctDNA
Circulating tumor DNA research, molecular residual disease, relapse monitoring, and cancer genomics.
Cancer genomics
Tumor sequencing, driver mutations, structural variants, biomarkers, and precision oncology.
Epigenetics
Chromatin biology, DNA methylation, histone marks, gene regulation, disease mechanisms, and therapy.
RNA therapeutics
siRNA, antisense oligonucleotides, mRNA, delivery systems, safety, and clinical translation.
Lipid nanoparticles
LNP delivery, mRNA vaccines, RNA therapeutics, formulation, biodistribution, and immunogenicity.
Protein design
Computational protein design, binders, enzymes, antibodies, structure prediction, and generative models.
AlphaFold
Protein structure prediction, complex modeling, structural biology, drug discovery, and method evaluation.
Computational biology
Models, algorithms, omics analysis, simulation, networks, and biological data interpretation.
Bioinformatics
Sequence analysis, omics workflows, databases, tools, algorithms, and reproducible biology.
Machine learning in biology
Machine learning for omics, protein design, imaging, prediction, and biological discovery.
Medical imaging AI
AI for radiology, pathology, imaging biomarkers, model validation, and clinical deployment.
Radiology AI
Radiology models, image interpretation, workflow triage, validation, safety, and clinical outcomes.
Digital pathology
Computational pathology, whole-slide imaging, biomarkers, tumor grading, and AI-assisted diagnosis.
Real-world evidence
Observational data, registries, claims, comparative effectiveness, safety, and clinical decision-making.
Health economics outcomes research
Cost effectiveness, quality of life, value assessment, access, and patient outcomes.
Antimicrobial resistance
Drug-resistant pathogens, surveillance, stewardship, diagnostics, mechanisms, and new antimicrobials.
Tuberculosis
TB diagnostics, vaccines, drug resistance, host response, treatment, and public health.
Long COVID
Post-acute COVID research, symptoms, mechanisms, biomarkers, rehabilitation, and clinical management.
Aging research
Biology of aging, senescence, longevity, biomarkers, interventions, and age-related disease.